Troy, N.Y. — Researchers have created organic gel nanomaterials that could be used to encapsulate pharmaceutical, food, and cosmetic products and to build 3-D biological scaffolds for tissue engineering. Using olive oil and six other liquid solvents, the scientists added a simple enzyme to chemically activate a sugar that changed the liquids to organic gels.

Scanning electron microscope images show organogel fibers in ethyl acetate (top) and self-supporting organogel scaffold after UV polymerization in ethyl acetate (bottom). Photo by Rensselaer/Dordick

“We are using the building blocks provided by nature to create new nanomaterials that are completely reversible and environmentally benign,” said Jonathan Dordick, the Howard P. Isermann ‘42 Professor of Chemical and Biological Engineering at Rensselaer Polytechnic Institute. “The importance of this finding is the ability to use the same naturally occurring enzyme both to create chemically functional organogels and to reverse the process and break down these gels into their biologically compatible building blocks.”

In the experiments, researchers activated a sugar using a simple enzyme, which generated a compound that self-assembles into 3-D fibers measuring approximately 50 nanometers in diameter. As the fibers entangle, a large amount of solvent gets packed together, trapping some 10,000 molecules.

The resulting organogel materials could be used as biocompatible scaffolds for tissue engineering and designing membranes, according to Dordick. Other possible applications include delivery systems for pharmaceuticals and preservatives for food and cosmetics.

“The development of new materials that are molecularly defined and chemically functional at the nanoscale is of critical importance to biological applications such as drug delivery,” said Dordick. “We are finding the natural world has provided tools to create these materials without the need to generate new compounds that may be harmful to the body or environment.” 

The findings are currently available online in advance of print publication July 17 by the journal Angewandte Chemie. 

Dordick’s research involves using enzyme technology to produce unique chemical structures with applications in drug discovery, materials science, and chemical technology.  

The research is led by Dordick and includes George John of the City University of New York; Guangyu Zhu, post-doctoral research associate at Rensselaer; and Jun Li of the University of Southern Mississippi. The paper is titled “Enzymatically Derived Sugar-Containing Self-Assembled Organogels with Nanostructured Morphologies.”

The funding for this research was provided by the National Science Foundation-funded Nanoscale Science and Engineering Center (NSEC) at Rensselaer, the Center for Directed Assembly of Nanostructures. 

Nanotechnology at Rensselaer
In September 2001, the National Science Foundation selected Rensselaer as one of the six original sites for a new Nanoscale Science and Engineering Center (NSEC). As part of the U.S. National Nanotechnology Initiative, the program is housed within the Rensselaer Nanotechnology Center and forms a partnership between Rensselaer, the University of Illinois at Urbana-Champaign, and Los Alamos National Laboratory. The mission of Rensselaer’s Center for Directed Assembly of Nanostructures is to integrate research, education, and technology dissemination, and to serve as a national resource for fundamental knowledge in directed assembly of nanostructures. The five other original NSECs are located at Harvard University, Columbia University, Cornell University, Northwestern University, and Rice University.

Biotechnology and Interdisciplinary Studies at Rensselaer
At Rensselaer, faculty and students in diverse academic and research disciplines are collaborating at the intersection of the life sciences and engineering to encourage discovery and innovation. Rensselaer’s four biotechnology research constellations - biocatalysis and metabolic engineering, functional tissue engineering and regenerative medicine, biocomputation and bioinformatics, and integrative systems biology - engage a multidisciplinary mix of faculty and students focused on the application of engineering and physical and information sciences to the life sciences. Ranked among the world’s most advanced research facilities, the Center for Biotechnology and Interdisciplinary Studies at Rensselaer provides a state-of-the-art platform for collaborative research and world-class programs and symposia.