Chemical Engineers at Rensselaer Polytechnic Institute Collaborate To Advance Battlefield Biomanufacturing Technology

Contact
Contact: Media Relations media@rpi.edu
Related Articles
Related
Chemical Engineers at Rensselaer Polytechnic Institute Collaborate To Advance Battlefield Biomanufacturing Technology
Rensselaer Professors Steven Cramer and Pankaj Karande Seek To Develop New Chemical Separations Technologies for Purification of Biological Therapeutics as Part of DARPA’s Biological Medicine on Demand (BioMoD) Program
Two chemical engineering professors at Rensselaer Polytechnic Institute are contributing to a collaboration among academia, industry, and the federal government to develop a method for rapidly manufacturing biologic drugs.
The project, funded by the Defense Advanced Research Projects Agency (DARPA) and led by the Massachusetts Institute of Technology (MIT), aims to provide front-line military medics with the ability to produce high-purity, high-potency drugs in as little as 24 hours. This capability would enable medics to be significantly more responsive to emergency situations and battlefield settings, where resources are often limited.
Rensselaer professors Steven Cramer and Pankaj Karande are among the academic research collaborators working on the project, which is led by MIT Professor J. Christopher Love, and funded with a $10.4 million grant as part of DARPA’s Biologically-derived Medicines On Demand (BioMOD) program.
“In this project, we are looking at ways of significantly simplifying and condensing several key steps of drug manufacturing and quality control. Our goal is to be able to create a small, easy-to-carry system that can synthesize needed drugs in 24 hours, instead of the six to 12 months it usually takes to create the same drugs in an industrial setting,” said Cramer, the William Weightman Walker Professor of Polymer Engineering at Rensselaer.
“The potential implications of this technology are far-reaching, as it will provide rapid access to drugs in remote settings, and have a direct effect in saving lives,” said Karande, assistant professor in the Howard P. Isermann Department of Chemical and Biological Engineering at Rensselaer.
Cramer and Karande, with their synergistic expertise in the areas of bioseparations, bioprocessing, peptide engineering, and drug discovery, will help work on the design of a new generation of specialized biomaterials that are highly selective and only bind with specific proteins. Combined with new advanced bioprocessing techniques, these advanced biomaterials are expected to help significantly reduce the number of processing steps required for purifying biologics secreted from host systems such as yeast.
The advances made in this project have the potential to change industrial downstream bioprocessing, as well as introduce new kinds of biomaterials with a broad range of applications in drug manufacturing, discovery, and development, the researchers said. Much of their research will take place in the Center for Biotechnology and Interdisciplinary Studies at Rensselaer.
Along with Cramer, Karande, and Love, additional academic collaborators on the BioMOD program include: MIT professors Richard Braatz, Jongyoon “Jay” Han, Tim Lu, Rajeev Ram, Anthony Sinskey and Michael Strano; and Northeastern University professor William Hancock. GK Raju of LightPharma and MIT Center for Biomedical Innovation’s (CBI) James C. Leung are both consultants on the project. Industrial collaborators include Pall Corporation and PerkinElmer. Latham BioPharm Group and the CBI will provide system integration.
For more information on the research of Cramer and Karande, visit:
- Cramer Labwww.rpi.edu/~crames
- Karande Labhttp://homepages.rpi.edu/~karanp/
- Fourth W.H. Peterson Award for Rensselaerhttp://www.rpi.edu/about/inside/issue/v4n4/peterson.html
- Purifying Proteins: Rensselaer Researchers Use NMR To Improve Drug Developmenthttp://news.rpi.edu/luwakkey/2772
- Rensselaer Professor Steven Cramer Elected Fellow of American Chemical Society - http://news.rpi.edu/luwakkey/3069
- Breaching the Blood-Brain Barrier To Create Powerful New Tools for Fighting Cancerhttp://news.rpi.edu/luwakkey/2754
- Biochemical Interactions of the Blood-Brain Barrier.http://youtu.be/NopbnN_DzS4
Contact
For general inquiries: newsmedia@rpi.edu
About Rensselaer Polytechnic Institute
Founded in 1824, Rensselaer Polytechnic Institute is America’s first technological research university. Rensselaer encompasses five schools, over 30 research centers, more than 140 academic programs including 25 new programs, and a dynamic community made up of over 6,800 students and 104,000 living alumni. Rensselaer faculty and alumni include upwards of 155 National Academy members, six members of the National Inventors Hall of Fame, six National Medal of Technology winners, five National Medal of Science winners, and a Nobel Prize winner in Physics. With nearly 200 years of experience advancing scientific and technological knowledge, Rensselaer remains focused on addressing global challenges with a spirit of ingenuity and collaboration. To learn more, please visit www.rpi.edu.