Armed with evidence that a specific site on heparan sulfate — known as the 3-O-sulfate group — is critical to the transfer of harmful tau proteins in the brain, a research program funded by the NIH’s National Institute of Aging is scrutinizing the interactions between heparan sulfate and tau, determining how misfolded tau spreads in the brain, and developing strategies to block it.
With support from the Warren Alpert Foundation, researchers at Rensselaer Polytechnic Institute have launched a search for drug candidates to block a biological process associated with Alzheimer’s disease.
A team of researchers led by Rensselaer Polytechnic Institute will examine the link between zinc deficiency, Hedgehog, and prostate cancer in a new study funded by the National Institutes of Health (NIH).
Zinc deficiency – long associated with numerous diseases, e.g. autism, lung cancer, prostate cancer, and ovarian cancers – can lead to activation of the Hedgehog signaling pathway.
"The mutations that cause FAD lead to an increased ratio of amyloid beta-42 over amyloid beta-40," Wang explains. "That's the biochemistry, and that has been observed by many people. But the question we asked is: how? How do the mutations lead to this increased ratio?"
About Rensselaer Polytechnic Institute
Founded in 1824, Rensselaer Polytechnic Institute is America’s first technological research university. Rensselaer encompasses five schools, 32 research centers, more than 145 academic programs, and a dynamic community made up of more than 7,600 students and more than 100,000 living alumni. Rensselaer faculty and alumni include more than 145 National Academy members, six members of the National Inventors Hall of Fame, six National Medal of Technology winners, five National Medal of Science winners, and a Nobel Prize winner in Physics. With nearly 200 years of experience advancing scientific and technological knowledge, Rensselaer remains focused on addressing global challenges with a spirit of ingenuity and collaboration.