A newly identified compound is a promising candidate for inhibiting the production of amyloids, the abnormal proteins that form toxic clumps, called fibrils, inside the brains of patients with Alzheimer’s disease. As published in the Royal Society of Chemistry’s Chemical Communications, the compound — known as “C1” — uses a novel mechanism to efficiently prevent the enzyme gamma-secretase from producing amyloids.
With support from the Warren Alpert Foundation, researchers at Rensselaer Polytechnic Institute have launched a search for drug candidates to block a biological process associated with Alzheimer’s disease.
A team of researchers led by Rensselaer Polytechnic Institute will examine the link between zinc deficiency, Hedgehog, and prostate cancer in a new study funded by the National Institutes of Health (NIH).
Zinc deficiency – long associated with numerous diseases, e.g. autism, lung cancer, prostate cancer, and ovarian cancers – can lead to activation of the Hedgehog signaling pathway.
New research, led by Chunyu Wang, has solved one mystery in the development of Familial Alzheimer’s Disease (FAD).