News

We all know how a bad night’s sleep can affect how we feel. In fact, the disruption of our sleep has been implicated at many levels of human disease, including cancer, diabetes, heart disease, and disorders associated with aging.

The brain’s ability to clear a protein closely linked to Alzheimer’s disease is tied to our circadian cycle, according to research published today in PLOS Genetics.

Having challenged the idea that our environment cannot alter our genetically controlled 24-hour sleep-wake cycle, circadian rhythm researcher Jennifer Hurley has embarked on a new project tracing the mechanism between environmental signals and the circadian clock.

An analysis of an exhaustive dataset on cells essential to the mammalian immune system shows that our ability to fight disease may rely more heavily on daily circadian cycles than previously assumed.

TROY, N.Y. — On a typical April day, Jackie Pelham would spend most of her time in a lab coat and goggles. Working at a laboratory bench, she would examine proteins found in the body. But lately, Pelham has traded her lab coat for a laptop and her lab bench for a desk in her home. Rather than observing biochemical processes, she is poring over previously collected data. Somewhat unexpectedly, even to her, Pelham sees this temporary trade-off as an opportunity.

A new frontier in the science of circadian rhythms – whose disruption is linked to major diseases like cancer and diabetes – suggests a previously unknown mechanism at work in our daily biological cycle.

Can environmental toxins disrupt circadian rhythms – the biological “clock” whose disturbance is linked to chronic inflammation and a host of human disorders? New research findings puts question squarely on the table.

In organisms from fungi to humans, the relationship between the genome, proteome, and matalome is heavily influenced by our internal circadian clock, and responds to environmental influences. 

The sleep/wake cycle of our circadian rhythm is a familiar concept, but less well known is that a circadian clock – a series of molecular events – can be found in nearly every living cell, from microbes to humans.