Rensselaer Polytechnic Institute’s Steven Cramer, William Weightman Walker Professor of Polymer Engineering, and Todd Przybycien, professor of chemical and biological engineering, will contribute to a three-year research program led by faculty at Massachusetts Institute of Technology (MIT) that aims to design the world’s first fully integrated, continuous mRNA manufacturing platform. Both Cramer and Przybycien are members of Rensselaer’s Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies. The platform is part of an $82 million effort funded by the U.S. Food and Drug Administration (FDA) Center for Biologics Evaluation and Research.

A team of researchers led by Rensselaer Polytechnic Institute’s Jonathan S. Dordick, Ph.D., Institute Professor of Chemical and Biological Engineering, has illuminated a new possibility for the treatment and prevention of COVID-19 in research published in Communications Biology.

Just as space holds infinite mysteries, when we zoom in at the level of biomolecules (one trillion times smaller than a meter), there is still so much to learn. Rensselaer Polytechnic Institute’s Catherine Royer, Constellation Chair Professor of Bioinformatics and Biocomputation at the Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS) and professor of biological sciences, is dedicated to understanding the conformational landscapes of biomolecules and how they modulate cell function. When biomolecules receive certain inputs, it can cause the atoms to rearrange and the biomolecule to change shape. This change in shape affects their function in cells, so understanding conformational dynamics is critical for drug development.

It is a scary fact that one in two women and one in three men in the United States will develop some form of cancer in their lifetime. One of the hallmarks of many cancers is the occurrence of errors during the cell division process called mitosis. Therefore, critical to enhancing treatments or perhaps even finding a cure for cancer and other diseases, is developing a better understanding of how mitosis works in both healthy and diseased cells.

Rensselaer Polytechnic Institute’s Christopher Cioffi, Ph.D., Thomas and Constance D’Ambra Professor in Organic Chemistry, has received a $2.5 million grant from the National Institutes of Health, along with Konstantin Petrukhin of Columbia University and Gennadiy Moiseyev of Wake Forest University. The grant will enable the team to design a drug to treat Stargardt disease, a rare retinal disorder.

Chunyu Wang, Ph.D., professor of biological sciences at Rensselaer Polytechnic Institute, has added to his body of research on Alzheimer’s disease with significant findings in Angewandte Chemie.

Researchers from Rensselaer Polytechnic Institute (RPI) and Albany Medical College were awarded a $3.3 million grant over five years by the National Cancer Institute to use artificial intelligence (AI) to improve targeted drug therapy in HER2-positive breast cancer treatment. HER2-positive breast cancer tends to grow and spread quickly, but targeted treatments improve outcomes.

Steven Cramer, the William Weightman Walker Professor of Polymer Engineering and a professor in the Isermann Department of Chemical and Biological Engineering at Rensselaer Polytechnic Institute (RPI), has been elected to the National Academy of Engineering for “scientific and technological advances leading to new chromatographic materials, processes, and predictive tools for the purification of biopharmaceuticals.”

In an article published in the Journal of Bone and Mineral Research, researchers at Rensselaer Polytechnic Institute (RPI) Dr. Deepak Vashishth and Joan Llabre, a Ph.D. student in the Department of Biomedical Engineering, presented evidence of a link between Alzheimer’s, osteoporosis, and diabetes. While recent evidence showed loss of bone mineral density with Alzheimer’s disease, this is the first study to demonstrate the effects of the Alzheimer’s disease phenotype on bone quality and link changes in bone and amyloid formation in the brain.

Researchers at Rensselaer Polytechnic Institute (RPI) have been awarded one of 12 grants for space biology research that will advance NASA’s understanding of how organisms respond, acclimate, and adapt in space. These projects will all support NASA’s human space exploration project.