Biotechnology and Life Sciences

New NIH Grant Supports Single Molecule Study of Protein Key to Alzheimer’s Disease

A new grant from the National Institute On Aging at the National Institutes of Health will support ongoing research at Rensselaer Polytechnic Institute to address Alzheimer’s disease caused by gene mutations. According to Chunyu Wang, the principal investigator and an assistant professor of biological sciences at Rensselaer, the project seeks to understand and counter the mechanism that produces Amyloid-Beta 42 peptide in brain cells.

New Research Aims To Combat Prion-like Spread of Tau Pathology in Alzheimer’s

Armed with evidence that a specific site on heparan sulfate — known as the 3-O-sulfate group — is critical to the transfer of harmful tau proteins in the brain, a research program funded by the NIH’s National Institute of Aging is scrutinizing the interactions between heparan sulfate and tau, determining how misfolded tau spreads in the brain, and developing strategies to block it.

Novel Compound is Promising Drug Candidate for Alzheimer’s Disease

A newly identified compound is a promising candidate for inhibiting the production of amyloids, the abnormal proteins that form toxic clumps, called fibrils, inside the brains of patients with Alzheimer’s disease. As published in the Royal Society of Chemistry’s Chemical Communications, the compound — known as “C1” — uses a novel mechanism to efficiently prevent the enzyme gamma-secretase from producing amyloids.

Rensselaer Announces New Degree Program in Biological Neuroscience

A new degree program in biological neuroscience at Rensselaer Polytechnic Institute explores the structure and function of the brain and nervous system. The major, which was recently approved by the New York State Education Department, will be offered beginning in the spring 2020 semester through the Rensselaer Department of Biological Sciences.

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