A new grant from the National Institute On Aging at the National Institutes of Health will support ongoing research at Rensselaer Polytechnic Institute to address Alzheimer’s disease caused by gene mutations. According to Chunyu Wang, the principal investigator and an assistant professor of biological sciences at Rensselaer, the project seeks to understand and counter the mechanism that produces Amyloid-Beta 42 peptide in brain cells.

As cancer and tumor cells move inside the human body, they impart and are subject to mechanical forces. In order to understand how these actions affect cancer cell growth, spread, and invasion, a team of engineers at Rensselaer Polytechnic Institute is developing new models that mimic aspects of the mechanical environment within the body, providing new insight into how and why tumors develop in certain ways.

Blood sample analysis showed that, two to five years after they gave birth, mothers of children with autism spectrum disorder (ASD) had several significantly different metabolite levels compared to mothers of typically developing children. That’s according to new research recently published in BMC Pediatrics by a multidisciplinary team from Rensselaer Polytechnic Institute, Arizona State University, and the Mayo Clinic.

An analysis of an exhaustive dataset on cells essential to the mammalian immune system shows that our ability to fight disease may rely more heavily on daily circadian cycles than previously assumed.

TROY, N.Y. — A loss of enzymatic processes within the body can increase a person’s risk of bone fracture. This new insight was recently published in eLife by an international team of scientists and engineers led by Deepak Vashishth, the director of the Center for Biotechnology and Interdisciplinary Studies (CBIS) at Rensselaer Polytechnic Institute.

An estimated 50 million people worldwide live with dementia, a syndrome that progressively affects a person’s cognitive function. Alzheimer’s disease is the most common form of dementia, but a full understanding of the mechanisms behind how and why it occurs remains elusive.

Ryan Gilbert, a professor of biomedical engineering at Rensselaer Polytechnic Institute, and X. George Xu, the Edward E. Hood Endowed Chair Professor Emeritus of mechanical, aerospace, and nuclear engineering, have been elected to the American Institute for Medical and Biological Engineering (AIMBE) 2021 class of fellows.

With communities across the nation experiencing a wave of COVID-19 infections, clinicians need effective tools that will enable them to aggressively and accurately treat each patient based on their specific disease presentation, health history, and medical risks.

For individuals with central nervous system paralysis, the effectiveness of neuroprosthetic technology — such as brain-controlled prosthetic limbs or muscle stimulation devices — makes a world of difference. If the process of implanting tiny electrodes in the brain were to be improved, allowing for stronger and longer lasting communication between neurons and external devices, it could significantly enhance quality of life.

Armed with evidence that a specific site on heparan sulfate — known as the 3-O-sulfate group — is critical to the transfer of harmful tau proteins in the brain, a research program funded by the NIH’s National Institute of Aging is scrutinizing the interactions between heparan sulfate and tau, determining how misfolded tau spreads in the brain, and developing strategies to block it.